How long does it take for domperidone to work? It depends on the situation. In a situation where the mother had a good milk supply, but it decreased for some reason (e.g. going on the birth control pill, see Slow Weight Gain After the First Few Months ), domperidone often works very rapidly to increase the milk supply. Galactagogues are foods, herbs or medications that may help to increase breastmilk supply. The use of a galactagogue requires consultation with a lactation consultant and/or medical adviser. Domperidone (Motilium™) has been around since the 1980s to treat gastric problems (e.g. nausea, vomiting, gastric reflux and gastric motility). It has not been used for nearly as long as a galactagogue. Domperidone helps to prevent you from feeling sick (nausea) or being sick (vomiting). It is recommended for short-term use only. Domperidone may be associated with an increased risk of heart rhythm disorder, particularly in older people. If you faint or feel that your heart is beating quickly, you Does domperidone work for everyone? No drug works for everyone in every situation or in the same way for different people, whether it be a drug for high blood pressure, an antibiotic to treat pneumonia, or any drug for any problem. Domperidone Introduction. Domperidone (Motilium™) is a drug that has, as a side effect, the increasing of milk production, probably by increasing prolactin production by the pituitary gland. Domperidone, Stopping. When domperidone was being used for babies (and now that cisapride is off the market, it is being used again), it was common for the babies to be on the medication for several months, even longer. How long does it take for domperidone to work? It depends on the situation. In a situation where the mother had a good milk supply, but it decreased for some reason (e.g. going on the birth control pill, see Slow Weight Gain After the First Few Months), domperidone often works very rapidly to increase the milk supply. I was told anything from a couple of days till a couple of weeks. I saw the results quickly though. A couple of days. I really put the work in,she was about the same age and for a week or two I fed pumped fed pumped. Domperidone. Introduction: Domperidone (Motilium™) is a drug that has, as a side effect, the increase of milk production, probably by increasing prolactin production by the pituitary gland.